Santiago Vilar-González, Oncology Department, Queen Alexandra Hospital, Cosham, UK
Abstract Systematic review of studies published in PubMed about the relationship between prostate cancer and anticoagulants, especially aspirin. We analyze the role that their association with radiation and hormone deprivation and his possible synergistic effect in treatment. We describe bibliographic evidence of possible association between aspirin use and the onset, development and mortality by prostate cancer. Continue delving into the pathophysiological mechanisms involved. Finally, we describe and discuss the works related to the association between anticoagulants, radiation and hormone deprivation. Randomized trials are guaranteed, taking into account disease-related, patients and therapies factors, in order to obtain unbiased evidence of their likely relationship. Once confirmed the hypothesis of its synergistic effect, in prevention and/or in adjuvant treatment setting of prostate cancer, it opens up a whole range of future possibilities of great impact in the management of this prevalent disease.
Keywords: Prostate cancer. Prostatic cancer. Aspirin. Anticoagulants. Nonsteroidal anti-inflammatory drugs. Antiaggregant drugs. Radiotherapy. Brachytherapy, irradiation, hormone deprivation. Androgen deprivation.
