Sylvia Salmun-Nehmad, Faculty of Health Sciences, Health Sciences Research Center (CICSA), Universidad Anáhuac México, State of Mexico, Mexico
Elías Gallardo-Navarro, Department of General Surgery, Hospital Español de la Ciudad de México, Mexico City, Mexico
Francisco M. García-Rodríguez, Department of Oncologic Surgery, Hospital Español de la Ciudad de México, Mexico City, Mexico
Carlos Mancera-Steiner, Department of Oncologic Surgery, Hospital Español de la Ciudad de México, Mexico City, Mexico
Jimena Ruiz de Chávez-Gascón, Faculty of Health Sciences, Health Sciences Research Center (CICSA), Universidad Anáhuac México, State of Mexico, Mexico
Adrián A. Carballo-Zarate, Department of Pathology, Hospital Español de la Ciudad de México, Mexico City, Mexico
América P. Bernal-Montalvo, Department of Pathology, Hospital Español de la Ciudad de México, Mexico City, Mexico

Angiosarcoma of the breast is a rare cancer, and there are two forms of presentation: the primary, where no identifiable precursor factors are associated, and the secondary, associated with radiotherapy. We report a case of a woman who developed a primary lesion 4 years after completing adjuvant radiotherapy for an infiltrating ductal carcinoma of the breast. She was conservatively treated with radical locoregional management, resulting in no residual disease; however, she exhibited a rapid tendency to systemic relapse, with conventional aromatase inhibitors proving to be ineffective. The treatment of choice is surgical, with which prolonged survival is sometimes achieved after complete resections.