Prolactin increases cell migration of MCF-7 cells without inducing an epithelium-mesenchyme transition
Jesús A. Lara-Reyes 1, Zuleima H. Castillo-García 2, Gonzalo E. Aranda-Abreu 3, Deissy Herrera-Covarrubias 3, Clara L. Sampieri-Ramírez 4, Arnoldo Aquino-Gálvez 5, Jorge M. Suárez-Medellín 3, Ma. Elena Hernández-Aguilar 3, Fausto Rojas-Durán 3
1 Brain Research, Universidad Veracruzana, Xalapa, Ver., Mexico; 2 Faculty of Bioanalysis, Universidad Veracruzana, Xalapa, Ver., Mexico; 3 Brain Research Institute, Universidad Veracruzana, Xalapa, Ver., Mexico; 4 Public Health Institute, Universidad Veracruzana, Xalapa, Ver., Mexico; 5 Molecular Biology Laboratory, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
Jesús A. Lara-Reyes, Zuleima H. Castillo-García, Gonzalo E. Aranda-Abreu, Deissy Herrera-Covarrubias, Clara L. Sampieri-Ramírez, Arnoldo Aquino-Gálvez, Jorge M. Suárez-Medellín, Ma. Elena Hernández-Aguilar, Fausto Rojas-Durán
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*Correspondencia: Arnoldo Aquino-Gálvez, Email no disponible
Resumen
Objective: To evaluate the effect of prolactin (PRL) on the migration of MCF-7 breast cancer cells and the expression of E-cadherin. Methods: We used the wound healing assays to evaluate the migration of MCF-7 cells and the Western blot technique to evaluate the expression of E-cadherin. Results: The results show that PRL produced an increase in the migration of MCF-7 cells without inducing a reduction in the expression of E-cadherin. Conclusions: Prolactin significantly increased the migration of MCF-7 breast cancer cell line without inducing an epithelial-mesenchymal transition (EMT), which could be related to a collective type of migration.
